Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27376941 | 0.86 | PTGS2 (0.44) | MKNK1MKNK2PTGS2 | |
| SCHEMBL8446139 | 0.85 | PTGS2 (0.40) | MKNK1MKNK2PTGS2SLC9A1 | |
| SCHEMBL8528490 | 0.81 | SLC9A1 (0.53) | SLC9A1 | |
| SCHEMBL8180285 | 0.80 | SLC9A1 (0.38) | SLC9A1 | |
| SCHEMBL8702013 | 0.80 | SLC2A1 (0.49) | MKNK1MKNK2PTGS2 | |
| SCHEMBL8699934 | 0.79 | SLC9A1 (0.40) | SLC9A1 | |
| SCHEMBL8532248 | 0.78 | SLC9A1 (0.48) | SLC9A1 | |
| SCHEMBL8444418 | 0.76 | SLC9A1 (0.54) | SLC9A1 | |
| SCHEMBL8446483 | 0.76 | SLC9A1 (0.54) | SLC9A1 | |
| SCHEMBL8533825 | 0.76 | SLC9A1 (0.55) | SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |
| EP-0699666-A1 | Heterocyclic substituted benzoylguanidine | MERCK PATENT GmbH (DE) | 1996-03-06 | — | — | EP | disclosed |