Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 3/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721482 | 0.89 | CYP2C19 (0.41) | MAPTADORA2BXDHENPP1POLB | |
| SCHEMBL7326384 | 0.85 | MAPT (0.43) | MAPTADORA2BXDHENPP1ACHE | |
| SCHEMBL7530553 | 0.81 | MAPT (0.46) | MAPTADORA2BXDHENPP1ACHE | |
| SCHEMBL1150739 | 0.81 | XDH (0.47) | MAPTADORA2BXDHACHEGDA | |
| SCHEMBL6233162 | 0.79 | XDH (0.51) | MAPTADORA2BXDHPARP1ALDH1A1 | |
| SCHEMBL31438586 | 0.78 | MAPT (0.48) | MAPTADORA2BXDHENPP1ACHE | |
| SCHEMBL380136 | 0.78 | MAPT (0.48) | MAPTADORA2BXDHACHEGDA | |
| SCHEMBL3118423 | 0.77 | XDH (0.54) | MAPTADORA2BXDHPARP1 | |
| SCHEMBL541696 | 0.77 | MAPT (0.42) | MAPTADORA2BXDHACHEGDA | |
| SCHEMBL11661802 | 0.76 | XDH (0.56) | MAPTXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710272-A | INCREASING CEREBRAL BLOOD FLOW | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
| US-5472873-A | Rhodotorula rubra useful in a process for the preparation of (ω-1)-hydroxyalkylxanthines | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-12-05 | — | — | US | disclosed |
| US-5310666-A | Vascular disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-05-10 | — | — | US | disclosed |