Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 3/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | GDA | Q9Y2T3 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8700368 | 0.85 | MAPT (0.42) | MAPTADORA2BXDHENPP1GDA | |
| SCHEMBL7329904 | 0.84 | XDH (0.43) | MAPTXDHPIM1ALDH1A1POLB | |
| SCHEMBL4014478 | 0.83 | MAPT (0.40) | MAPTADORA2BXDHENPP1GDA | |
| SCHEMBL9721482 | 0.81 | CYP2C19 (0.41) | MAPTADORA2BXDHENPP1ALDH1A1 | |
| SCHEMBL31438586 | 0.79 | MAPT (0.48) | MAPTADORA2BXDHENPP1GDA | |
| SCHEMBL380136 | 0.79 | MAPT (0.48) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL8884684 | 0.77 | MAPT (0.47) | MAPTADORA2BXDHENPP1GDA | |
| SCHEMBL985622 | 0.76 | ADORA2B (0.51) | MAPTADORA2BXDHALDH1A1POLB | |
| SCHEMBL1150739 | 0.76 | XDH (0.47) | MAPTADORA2BXDHGDAACHE | |
| SCHEMBL7530553 | 0.76 | MAPT (0.46) | MAPTADORA2BXDHENPP1GDA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0485495-A1 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | Beecham Group p.l.c. (GB) | 1992-05-20 | — | — | EP | disclosed |
| WO-1991001730-A2 | USE OF XANTHINE-DERIVATIVES AS INHIBITORS OF INDUCED BLOOD EOSINOPHILIA | BEECHAM GROUP PLC (GB) | 1991-02-21 | — | — | WO | disclosed |
| EP-0267676-A2 | Use of 1,3-di-n-butyl-7-(2-oxypropyl) xanthine in the treatment of cerebrovascular or cerebral senility associated disorders, peripheral vascular disease and proliferative skin diseases | Beecham Wuelfing GmbH & Co KG (DE) | 1988-05-18 | — | — | EP | disclosed |
| EP-0260127-A2 | Xanthine derivatives, their preparation and pharmaceutical compositions containing them | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1988-03-16 | — | — | EP | disclosed |