SCHEMBL8700766

SCHEMBL8700766

O=C(CCCl)Nc1cccc2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.64

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.64
ALDH1A1 P00352 1/20 0.64
POLB P06746 1/20 0.64
GAA P10253 1/20 0.64
MAPT P10636 1/20 0.64
DNMT1 P26358 1/20 0.64
RAD52 P43351 1/20 0.64
SMARCA2 P51531 1/20 0.64
KMT2A Q03164 1/20 0.64
TERT O14746 13/20 0.63
MAOA P21397 1/20 0.61
PTPRC P08575 1/20 0.58
PTPN13 Q12923 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8707594 0.95 TERT (0.68) MEN1ALDH1A1POLBGAAMAPT
SCHEMBL1304418 0.94 TERT (0.69) MEN1ALDH1A1POLBGAAMAPT
SCHEMBL8707320 0.92 MEN1 (0.62) MEN1ALDH1A1POLBGAAMAPT
SCHEMBL14240480 0.90 TERT (0.66) MEN1ALDH1A1POLBGAAMAPT
SCHEMBL30237734 0.89 TERT (0.65) MEN1ALDH1A1POLBGAAMAPT
SCHEMBL6367460 0.89 TERT (0.65) MEN1ALDH1A1POLBGAAMAPT
SCHEMBL12111899 0.89 TERT (0.67) MEN1ALDH1A1POLBGAAMAPT
SCHEMBL3381039 0.88 MAOA (0.65) MEN1ALDH1A1POLBGAAMAPT
SCHEMBL12111904 0.87 TERT (0.61) MEN1ALDH1A1POLBGAAMAPT
SCHEMBL5804635 0.85 MEN1 (0.68) MEN1ALDH1A1POLBGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120316234-A1 ANTHRAQUINONE -BASED COMPOUND, THE SYNTHESIS PROCESSES AND THE APPLICATION THEREOF NATIONAL DEFENSE MEDICAL CENTER (TW) 2012-12-13 US disclosed
WO-1998025884-A1 FURTHER ANTHRAQUINONES WITH BIOLOGICAL ACTIVITY CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1998-06-18 WO disclosed
WO-1998025885-A1 ANTHRAQUINONES WITH BIOLOGICAL ACTIVITY CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1998-06-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120316234-A1 ANTHRAQUINONE -BASED COMPOUND, THE SYNTHESIS PROCESSES AND THE APPLICATION THEREOF AAAS, QPCT, NQO2 MEN1 2110/4885ALDH1A1 1002/4885POLB 2349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.