Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 12/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8260354 | 0.73 | LTB4R2 (0.52) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL8092930 | 0.73 | LTB4R2 (0.49) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL9486277 | 0.73 | LTB4R2 (0.44) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL2976631 | 0.71 | AGTR1 (0.53) | LTB4R2AGTR1ABCB11GP6AGTR2 | |
| SCHEMBL684200 | 0.70 | LTB4R2 (0.50) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL28463355 | 0.70 | LTB4R2 (0.51) | LTB4R2AGTR1ABCB11GP6 | |
| SCHEMBL2969136 | 0.70 | AGTR1 (0.58) | LTB4R2AGTR1ABCB11GP6AGTR2 | |
| SCHEMBL2969141 | 0.70 | AGTR1 (0.54) | LTB4R2AGTR1ABCB11GP6AGTR2 | |
| SCHEMBL18425480 | 0.69 | LTB4R2 (0.69) | LTB4R2AGTR1 | |
| SCHEMBL14051316 | 0.69 | AGTR1 (0.44) | LTB4R2AGTR1ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |