Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 1.00 |
| ▸ | NPC1 | O15118 | 9/20 | 1.00 |
| ▸ | CA12 | O43570 | 7/20 | 1.00 |
| ▸ | CA9 | Q16790 | 5/20 | 1.00 |
| ▸ | CA1 | P00915 | 3/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 2/20 | 0.63 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11142139 | 0.89 | RAB9A (1.00) | RAB9ANPC1CA12CA9CA1 | |
| SCHEMBL9168762 | 0.88 | RAB9A (0.86) | RAB9ANPC1CA12CA9CA1 | |
| SCHEMBL9164213 | 0.86 | RAB9A (0.80) | RAB9ANPC1CA12CA9CA1 | |
| SCHEMBL11144818 | 0.86 | RAB9A (0.84) | RAB9ANPC1CA12CA9CA1 | |
| SCHEMBL9251443 | 0.86 | RAB9A (0.80) | RAB9ANPC1CA12CA9CA1 | |
| SCHEMBL9983466 | 0.82 | RAB9A (0.73) | RAB9ANPC1CA12CA9CA1 | |
| SCHEMBL9014634 | 0.81 | RAB9A (0.76) | RAB9ANPC1CA12CA9CA1 | |
| SCHEMBL9769427 | 0.78 | CA12 (1.00) | RAB9ANPC1CA12CA9CA1 | |
| SCHEMBL10908945 | 0.77 | CA12 (1.00) | RAB9ANPC1CA12CA9CA1 | |
| SCHEMBL25989104 | 0.75 | RAB9A (0.62) | RAB9ANPC1CA12CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |