Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.76 |
| ▸ | NPC1 | O15118 | 7/20 | 0.76 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.76 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.71 |
| ▸ | CA12 | O43570 | 5/20 | 0.70 |
| ▸ | CA9 | Q16790 | 4/20 | 0.70 |
| ▸ | CA2 | P00918 | 2/20 | 0.70 |
| ▸ | CA1 | P00915 | 2/20 | 0.68 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | ELANE | P08246 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029127 | 0.86 | CA12 (0.67) | CA12CA9CA2CA1KMT2A | |
| SCHEMBL11142139 | 0.83 | RAB9A (1.00) | RAB9ANPC1HSP90AA1PAX8CA12 | |
| SCHEMBL14884779 | 0.82 | CA12 (1.00) | RAB9ANPC1HSP90AA1PAX8CA12 | |
| SCHEMBL29463843 | 0.82 | CA12 (1.00) | RAB9ANPC1HSP90AA1PAX8CA12 | |
| SCHEMBL9168762 | 0.82 | RAB9A (0.86) | RAB9ANPC1HSP90AA1PAX8CA12 | |
| SCHEMBL9251443 | 0.81 | RAB9A (0.80) | RAB9ANPC1HSP90AA1PAX8CA12 | |
| SCHEMBL9164213 | 0.81 | RAB9A (0.80) | RAB9ANPC1HSP90AA1PAX8CA12 | |
| SCHEMBL8701092 | 0.81 | RAB9A (1.00) | RAB9ANPC1HSP90AA1PAX8CA12 | |
| SCHEMBL11144818 | 0.81 | RAB9A (0.84) | RAB9ANPC1HSP90AA1PAX8CA12 | |
| SCHEMBL7289248 | 0.77 | ELANE (1.00) | RAB9ANPC1CA12CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0585155-B1 | Trifluoromethylketone derivatives of peptides having HLE inhibiting activity, their preparation and pharmaceutical composition | ADIR (FR) | 1996-12-11 | — | — | EP | disclosed |
| US-5565429-A | HUMAN LEUCOCYTE ELASTASE INHIBITORS; EMPHYSEMA; ANTIARTHRITIC AGENTS; RHEUMATIC DISEASES | ADIR ET COMPAGNIE (FR) | 1996-10-15 | — | — | US | disclosed |
| EP-0585155-A1 | Trifluoromethylketone derivatives of peptides having HLE inhibiting activity, their preparation and pharmaceutical composition | ADIR ET COMPAGNIE (FR) | 1994-03-02 | — | — | EP | disclosed |