Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394949 | 0.86 | FOLH1 (0.51) | TSHRAKR1B1FOLH1PPARGPPARA | |
| SCHEMBL11143386 | 0.85 | AKR1B1 (0.55) | TSHRAKR1B1PLA2G10PLA2G2A | |
| SCHEMBL4861257 | 0.83 | TSHR (0.70) | TSHRPLA2G2ACA1CA2CA9 | |
| SCHEMBL23003 | 0.82 | TSHR (0.79) | TSHRCA1CA2CA9PTPN1 | |
| SCHEMBL9566231 | 0.82 | AKR1B1 (0.52) | TSHRAKR1B1PLA2G10PLA2G2APTPN1 | |
| SCHEMBL4557746 | 0.81 | AKR1B1 (0.64) | TSHRAKR1B1PLA2G10PLA2G2AHNF4A | |
| Ammonia Solution, Strong SCHEMBL27527756 | 0.81 | TSHR (0.76) | TSHRCA1CA2CA9PTPN1 | |
| SCHEMBL28370887 | 0.81 | TSHR (0.76) | TSHRCA1CA2CA9PTPN1 | |
| SCHEMBL2628166 | 0.81 | TSHR (0.57) | TSHRCA1CA2CA9PTPN1 | |
| SCHEMBL7374000 | 0.81 | TSHR (0.57) | TSHRCA1CA2CA9PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827868-A | Prostaglandin analogs | E. R. SQUIBB & SONS, INC. (US) | 1998-10-27 | — | — | US | disclosed |
| EP-0536713-A1 | Oxazole and imidazole derivatives as prostaglandin analogs | E.R. SQUIBB & SONS, INC. (US) | 1993-04-14 | — | — | EP | disclosed |