SCHEMBL4861257

SCHEMBL4861257

O=C(O)c1cccc(Cc2ccccc2C(=O)O)c1

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.70
FOLH1 Q04609 2/20 0.56
PTPN1 P18031 3/20 0.50
KDM4E B2RXH2 1/20 0.50
PLA2G2A P14555 1/20 0.49
CA1 P00915 2/20 0.49
CA2 P00918 2/20 0.49
CA9 Q16790 2/20 0.49
KMT2A Q03164 1/20 0.49
PTPN2 P17706 1/20 0.49
PTPN6 P29350 1/20 0.49
NR4A2 P43354 1/20 0.49
AKR1C3 P42330 1/20 0.48
HNF4A P41235 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzoic Acid SCHEMBL29974267 0.89 TSHR (0.86) TSHRFOLH1PTPN1KDM4ECA1
SCHEMBL23003 0.85 TSHR (0.79) TSHRFOLH1PTPN1CA1CA2
SCHEMBL7765745 0.85 FOLH1 (0.54) TSHRFOLH1KMT2ANR4A2
SCHEMBL28370887 0.83 TSHR (0.76) TSHRFOLH1PTPN1CA1CA2
Ammonia Solution, Strong SCHEMBL27527756 0.83 TSHR (0.76) TSHRFOLH1PTPN1CA1CA2
SCHEMBL1926951 0.83 FOLH1 (0.66) FOLH1PLA2G2ACA1CA2CA9
SCHEMBL3779950 0.83 FOLH1 (0.53) TSHRFOLH1PTPN1PLA2G2ACA1
SCHEMBL8701316 0.83 TSHR (0.57) TSHRFOLH1PTPN1PLA2G2ACA1
SCHEMBL2628166 0.83 TSHR (0.57) TSHRFOLH1PTPN1KDM4ECA1
SCHEMBL7374000 0.83 TSHR (0.57) TSHRPTPN1CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7402376-B2 Photosensitive resin composition and photosensitive dry film containing the same TOKYO OHKA KOGYO CO., LTD. (JP) 2008-07-22 US disclosed
US-7348456-B2 Substituted amides MERCK & CO., INC. (US) 2008-03-25 US disclosed
US-20060106071-A1 Substituted amides MERCK SHARP & DOHME CORP. 2006-05-18 US disclosed
US-20050238998-A1 Photosensitive resin composition and photosensitive dry film containing the same TOKYO OHKA KOGYO CO., LTD. (JP) 2005-10-27 US disclosed
US-20040152862-A1 Optical resins and applications thereof HITACHI CHEMICAL CO., LTD. (JP) 2004-08-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060106071-A1 Substituted amides CNR1, CNR2, FAAH TSHR 651/4885FOLH1 3075/4885PTPN1 2788/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.