Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.52 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697624 | 0.84 | CYP19A1 (0.50) | CYP19A1CYP26A1CYP17A1TSHR | |
| SCHEMBL8698220 | 0.83 | CYP19A1 (0.69) | CYP19A1CYP26A1NPC1TSHRMAPK1 | |
| SCHEMBL8697755 | 0.81 | CYP19A1 (0.73) | CYP19A1CYP26A1CYP3A4 | |
| SCHEMBL8696281 | 0.76 | CYP19A1 (0.56) | CYP19A1CYP26A1NPC1RAB9ACYP24A1 | |
| SCHEMBL8702874 | 0.76 | IDO1 (0.35) | CYP19A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8697952 | 0.76 | IDO1 (0.33) | NPC1RAB9ATSHRCYP3A4MEN1 | |
| SCHEMBL8697855 | 0.75 | CYP19A1 (0.40) | CYP19A1NPC1RAB9ATSHRMAPK1 | |
| SCHEMBL8700053 | 0.73 | CYP19A1 (0.51) | CYP19A1CYP26A1CYP17A1TSHR | |
| SCHEMBL8696295 | 0.72 | CYP19A1 (0.65) | CYP19A1CYP26A1NPC1RAB9A | |
| SCHEMBL8696639 | 0.72 | CYP19A1 (0.73) | CYP19A1CYP26A1CYP24A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | disclosed |