Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 13/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8697624 | 0.87 | CYP19A1 (0.50) | CYP19A1KDM4EALDH1A1PKMHPGD | |
| SCHEMBL8697493 | 0.83 | CYP19A1 (0.67) | CYP19A1TSHRCYP2A6CYP26A1CYP1A2 | |
| SCHEMBL8700529 | 0.82 | CYP19A1 (0.73) | CYP19A1TSHRCYP26A1CYP1A2CYP2C19 | |
| SCHEMBL8702011 | 0.78 | FLT1 (0.34) | CYP19A1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL8697611 | 0.78 | ALDH1A1 (0.33) | CYP19A1ALDH1A1CYP2A6 | |
| SCHEMBL8702186 | 0.74 | CYP19A1 (0.47) | CYP19A1KDM4EALDH1A1PKMHPGD | |
| SCHEMBL8701925 | 0.73 | CYP19A1 (0.52) | CYP19A1TSHRCYP26A1CYP17A1 | |
| SCHEMBL8696281 | 0.73 | CYP19A1 (0.56) | CYP19A1ALDH1A1CYP26A1 | |
| SCHEMBL8702245 | 0.70 | CYP19A1 (0.72) | CYP19A1TSHRCYP26A1CYP1A2CYP2C19 | |
| SCHEMBL8696295 | 0.69 | CYP19A1 (0.65) | CYP19A1KDM4EALDH1A1HPGDCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998018791-A1 | HETEROCYCLIC FURAN COMPOUNDS, THEIR PREPARATION AND USE AS AROMATASE INHIBITORS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1998-05-07 | — | — | WO | disclosed |