Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SQLE | Q14534 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 3/20 | 0.38 |
| ▸ | FNTB | P49356 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8702915 | 1.00 | SQLE (0.43) | SQLEKMT2ALSSKDM1AMAPT | |
| SCHEMBL26115976 | 0.88 | — | — | |
| SCHEMBL530927 | 0.82 | KMT2A (0.64) | SQLEKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL7757953 | 0.82 | KMT2A (0.64) | SQLEKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL530928 | 0.82 | KMT2A (0.64) | SQLEKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL23151826 | 0.80 | CES2 (0.44) | KMT2AALDH1A1MEN1ALOX15 | |
| SCHEMBL2638546 | 0.80 | CES2 (0.44) | KMT2AALDH1A1MEN1ALOX15 | |
| SCHEMBL19990986 | 0.80 | CES2 (0.44) | KMT2AALDH1A1MEN1ALOX15 | |
| SCHEMBL2638548 | 0.80 | CES2 (0.44) | KMT2AALDH1A1MEN1ALOX15 | |
| SCHEMBL11553059 | 0.79 | KDM1A (0.50) | SQLEKMT2ALSSKDM1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834433-A | ANTITUMOR AND -CARCINOMA AGENTS; SMALL CELL LUNG AND PROSTATIC CARCINOMA; ANTIMIOTIC AND ANTISECRETORY AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1998-11-10 | — | — | US | disclosed |
| EP-0468497-B1 | Peptide-antagonists of bombesin/GRP | MERRELL PHARMA INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0468497-A2 | Peptide-antagonists of bombesin/GRP | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |