Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.71 |
| ▸ | DRD3 | P35462 | 7/20 | 0.71 |
| ▸ | DRD2 | P14416 | 5/20 | 0.71 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704278 | 0.93 | DRD4 (0.62) | DRD4DRD3DRD2KDM4EMEN1 | |
| SCHEMBL8709286 | 0.89 | DRD4 (0.88) | DRD4DRD3DRD2KDM4EMEN1 | |
| SCHEMBL8709280 | 0.83 | DRD4 (0.74) | DRD4DRD3DRD2MEN1KMT2A | |
| SCHEMBL8709397 | 0.83 | DRD4 (1.00) | DRD4DRD3DRD2KDM4EMEN1 | |
| SCHEMBL8705140 | 0.81 | DRD4 (1.00) | DRD4DRD3DRD2KDM4EMEN1 | |
| SCHEMBL8709395 | 0.77 | DRD4 (0.84) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8704932 | 0.75 | DRD4 (1.00) | DRD4DRD3DRD2MAPTHTR6 | |
| SCHEMBL8705132 | 0.75 | DRD4 (0.83) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8708195 | 0.75 | DRD4 (1.00) | DRD4DRD3DRD2MAPTHTR6 | |
| SCHEMBL8704454 | 0.75 | DRD4 (0.79) | DRD4DRD3DRD2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849765-A | Tetrahydropyridine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-15 | — | — | US | disclosed |