Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 13/20 | 1.00 |
| ▸ | DRD3 | P35462 | 10/20 | 1.00 |
| ▸ | DRD2 | P14416 | 9/20 | 1.00 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709286 | 0.94 | DRD4 (0.88) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8705140 | 0.93 | DRD4 (1.00) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8709395 | 0.91 | DRD4 (0.84) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8704454 | 0.88 | DRD4 (0.79) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8704932 | 0.87 | DRD4 (1.00) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8708195 | 0.86 | DRD4 (1.00) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8709280 | 0.85 | DRD4 (0.74) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8705132 | 0.84 | DRD4 (0.83) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8704281 | 0.83 | DRD4 (0.71) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8706116 | 0.82 | DRD2 (0.79) | DRD4DRD3DRD2CYP3A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849765-A | Tetrahydropyridine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-15 | — | — | US | disclosed |