Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 11/20 | 0.83 |
| ▸ | DRD3 | P35462 | 8/20 | 0.83 |
| ▸ | DRD2 | P14416 | 7/20 | 0.83 |
| ▸ | HTR6 | P50406 | 4/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709395 | 0.93 | DRD4 (0.84) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8709280 | 0.91 | DRD4 (0.74) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8705140 | 0.91 | DRD4 (1.00) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8706109 | 0.88 | DRD2 (0.69) | DRD4DRD3DRD2HTR6HTR1A | |
| SCHEMBL8708195 | 0.88 | DRD4 (1.00) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8704445 | 0.86 | DRD4 (0.66) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8709397 | 0.84 | DRD4 (1.00) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8709286 | 0.82 | DRD4 (0.88) | DRD4DRD3DRD2HTR6OPRM1 | |
| SCHEMBL8706116 | 0.82 | DRD2 (0.79) | DRD4DRD3DRD2HTR1A | |
| SCHEMBL8704278 | 0.81 | DRD4 (0.62) | DRD4DRD3DRD2HTR6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849765-A | Tetrahydropyridine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME, LTD. (GB) | 1998-12-15 | — | — | US | disclosed |