Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | SHH | Q15465 | 1/20 | 0.50 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.50 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.50 |
| ▸ | SMO | Q99835 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8700409 | 0.86 | KAT6A (0.44) | SLC6A3ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL8700161 | 0.85 | MAPT (0.39) | SLC6A3ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL30304318 | 0.82 | NTRK1 (0.51) | SLC6A3ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL17239448 | 0.82 | NTRK1 (0.51) | SLC6A3ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL8444808 | 0.81 | — | — | |
| SCHEMBL17239501 | 0.80 | NTRK1 (0.53) | SLC6A3ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL8183869 | 0.79 | P2RX4 (0.43) | MAPTNPSR1 | |
| SCHEMBL17239474 | 0.79 | NTRK1 (0.56) | SLC6A3AXLGABRG2GABRB3GABRA3 | |
| SCHEMBL17239550 | 0.79 | NTRK1 (0.53) | — | |
| SCHEMBL8699627 | 0.79 | CYP46A1 (0.51) | SLC6A3TYK2AXLGABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |