Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 5/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | SDHB | P21912 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | SHH | Q15465 | 1/20 | 0.41 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704331 | 0.86 | SLC6A3 (0.50) | JAK1TYK2AXLSDHBGABRG2 | |
| SCHEMBL8447990 | 0.81 | SLC9A1 (0.47) | — | |
| SCHEMBL8894494 | 0.79 | PTGS2 (0.49) | JAK1TYK2GRM5GAAMAPT | |
| SCHEMBL8704080 | 0.79 | CFTR (0.50) | GABRG2GABRB3GABRA3LMNA | |
| SCHEMBL205611 | 0.75 | AXL (0.57) | KAT6AAXLGABRG2GABRB3GABRA3 | |
| SCHEMBL17239550 | 0.74 | NTRK1 (0.53) | — | |
| SCHEMBL29694130 | 0.73 | SLC6A3 (0.55) | AXLSDHBGABRG2GABRB3GABRA3 | |
| SCHEMBL5234641 | 0.73 | SLC6A3 (0.55) | AXLSDHBGABRG2GABRB3GABRA3 | |
| SCHEMBL8700008 | 0.73 | GABRG2 (0.43) | JAK1TYK2AXLSDHBGABRG2 | |
| SCHEMBL3551797 | 0.73 | SLC6A3 (0.52) | KAT6AAXLGABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |