Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033671 | 0.87 | JAK3 (0.34) | JAK3JAK2JAK1CHEK1NTRK1 | |
| SCHEMBL8414954 | 0.85 | JAK3 (0.37) | JAK3JAK2JAK1CHEK1NTRK1 | |
| SCHEMBL8705045 | 0.81 | MEN1 (0.35) | JAK3JAK2JAK1 | |
| SCHEMBL8705292 | 0.81 | TSHR (0.35) | JAK3JAK2JAK1 | |
| SCHEMBL9034315 | 0.75 | JAK3 (0.33) | JAK3JAK2JAK1CHEK1NTRK1 | |
| SCHEMBL8416637 | 0.70 | MEN1 (0.36) | JAK3JAK2JAK1 | |
| SCHEMBL8840396 | 0.70 | MEN1 (0.33) | JAK3JAK2JAK1 | |
| SCHEMBL8840572 | 0.70 | JAK2 (0.31) | JAK3JAK2JAK1 | |
| SCHEMBL9035643 | 0.70 | ALDH1A1 (0.33) | JAK3JAK2JAK1 | |
| SCHEMBL8417787 | 0.69 | JAK3 (0.37) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5723450-A | Substituted pyridines, their preparation, and their use as pesticides and fungicides | HOECHST SCHERING AGREVO GMBH (DE) | 1998-03-03 | — | — | US | disclosed |