Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.41 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705954 | 0.90 | ESR1 (0.47) | ALDH1A1GAAESR1MAPTLTA4H | |
| SCHEMBL8325256 | 0.90 | ALDH1A1 (0.46) | ALDH1A1GAAESR1MAPTLTA4H | |
| SCHEMBL13412705 | 0.87 | NR5A1 (0.51) | ALDH1A1GAAESR1MAPTLTA4H | |
| SCHEMBL9573819 | 0.86 | GAA (0.45) | ALDH1A1GAAESR1HPGDGLA | |
| SCHEMBL9191296 | 0.86 | GAA (0.64) | ALDH1A1GAAESR1MAPTMAPK1 | |
| SCHEMBL8705625 | 0.85 | ALDH1A1 (0.63) | ALDH1A1GAAESR1MAPTHPGD | |
| SCHEMBL9428158 | 0.83 | GAA (0.41) | ALDH1A1GAAESR1HPGDGLA | |
| SCHEMBL8802445 | 0.83 | GAA (0.54) | ALDH1A1GAAESR1MAPTHPGD | |
| SCHEMBL8809032 | 0.83 | GAA (0.49) | ALDH1A1GAAESR1MAPTMAPK1 | |
| SCHEMBL8707515 | 0.82 | ALDH1A1 (0.47) | ALDH1A1GAAESR1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5717112-A | Benzofuranone and benzodifuranone compounds | ZENECA LIMITED (GB) | 1998-02-10 | — | — | US | disclosed |
| EP-0669922-B1 | BENZOFURANONES, BENZODIFURANTRIONES AND PROCESSES FOR THE PREPARATION OF BENZODIFURANDIONES | BASF AG (DE) | 1997-08-20 | — | — | EP | disclosed |
| US-5625080-A | Benzodifurantrione compounds and process | ZENECA LIMITED (GB) | 1997-04-29 | — | — | US | disclosed |
| EP-0669922-A1 | BENZOFURANONE AND BENZODIFURANTRIONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF BENZODIFURANONES. | ZENECA LTD (GB) | 1995-09-06 | — | — | EP | disclosed |
| US-5367008-A | 3-(alkoxyphenyl)benzofuran-2-ones as stabilisers | CIBA-GEIGY CORPORATION (US) | 1994-11-22 | — | — | US | disclosed |
| WO-1994012501-A1 | BENZOFURANONE AND BENZODIFURANTRIONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF BENZODIFURANONES | ZENECA LIMITED (GB) | 1994-06-09 | — | — | WO | disclosed |