Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EBP | Q15125 | 6/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ESR1 | P03372 | 6/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.45 |
| ▸ | DHCR7 | Q9UBM7 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10879788 | 0.88 | KMT2A (0.53) | EBPSIGMAR1CYP2D6HTTCYP1A2 | |
| SCHEMBL330094 | 0.86 | SIGMAR1 (0.67) | EBPSIGMAR1CYP2D6HTTCYP1A2 | |
| SCHEMBL16910242 | 0.84 | SIGMAR1 (0.69) | EBPSIGMAR1CYP2D6HTTCYP1A2 | |
| SCHEMBL6769894 | 0.82 | CYP2D6 (0.48) | EBPSIGMAR1CYP2D6HTTCYP1A2 | |
| SCHEMBL4314565 | 0.82 | EBP (0.53) | EBPSIGMAR1CYP2D6HTTCYP1A2 | |
| SCHEMBL10880305 | 0.82 | MEN1 (0.52) | EBPSIGMAR1CYP2D6HTTCYP1A2 | |
| SCHEMBL6009065 | 0.81 | CYP2D6 (0.51) | EBPSIGMAR1CYP2D6HTTCYP1A2 | |
| SCHEMBL7753432 | 0.78 | SIGMAR1 (0.79) | EBPSIGMAR1CYP2D6HTTCYP1A2 | |
| SCHEMBL2896442 | 0.78 | CYP2D6 (0.54) | EBPSIGMAR1CYP2D6HTTCYP1A2 | |
| SCHEMBL3294808 | 0.78 | CYP2D6 (0.54) | EBPSIGMAR1CYP2D6HTTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998046588-A2 | COMPOUNDS AND THERAPIES FOR THE PREVENTION OF VASCULAR AND NON-VASCULAR PATHOLOGIES | NEORX CORPORATION (US) | 1998-10-22 | — | — | WO | disclosed |
| EP-0833624-A2 | PREVENTION AND TREATMENT OF CARDIOVASCULAR PATHOLOGIES WITH TAMOXIFEN ANALOGUES | NEORX CORPORATION (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996040098-A2 | PREVENTION AND TREATMENT OF CARDIOVASCULAR PATHOLOGIES WITH TAMOXIFEN ANALOGUES | NEORX CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |