Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8707305 | 1.00 | P2RX3 (0.45) | P2RX3ALDH1A1TDP1POLBEPHX2 | |
| SCHEMBL5517458 | 0.88 | POLB (0.52) | ALDH1A1TDP1POLBEPHX2MEN1 | |
| SCHEMBL10148089 | 0.88 | POLB (0.52) | ALDH1A1TDP1POLBEPHX2MEN1 | |
| SCHEMBL8707251 | 0.87 | GAA (0.49) | P2RX3ALDH1A1TDP1POLBMEN1 | |
| SCHEMBL8707255 | 0.87 | GAA (0.49) | P2RX3ALDH1A1TDP1POLBMEN1 | |
| SCHEMBL31381177 | 0.85 | P2RX3 (0.57) | P2RX3ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL31381172 | 0.85 | P2RX3 (0.57) | P2RX3ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL12964792 | 0.85 | TSHR (0.48) | P2RX3ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL14235510 | 0.82 | P2RX3 (0.45) | P2RX3POLBKMT2AGRIN1GRIN2B | |
| SCHEMBL16711254 | 0.82 | HRH3 (0.50) | P2RX3ALDH1A1POLBEPHX2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693054-B1 | CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5681858-A | Cycloalkyl hydroxyureas | PFIZER INC. (US) | 1997-10-28 | — | — | US | disclosed |