Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8707251 | 1.00 | GAA (0.49) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL31381172 | 0.87 | P2RX3 (0.57) | SMN1; SMN2ALDH1A1POLBP2RX3KMT2A | |
| SCHEMBL31381177 | 0.87 | P2RX3 (0.57) | SMN1; SMN2ALDH1A1POLBP2RX3KMT2A | |
| SCHEMBL8707307 | 0.87 | P2RX3 (0.45) | ALDH1A1POLBTDP1P2RX3KMT2A | |
| SCHEMBL8707305 | 0.87 | P2RX3 (0.45) | ALDH1A1POLBTDP1P2RX3KMT2A | |
| SCHEMBL12964792 | 0.86 | TSHR (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1P2RX3 | |
| SCHEMBL14235510 | 0.84 | P2RX3 (0.45) | GAANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL16686018 | 0.83 | GAA (0.46) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22340201 | 0.83 | ALDH1A1 (0.41) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22340149 | 0.83 | ALDH1A1 (0.41) | GAANPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693054-B1 | CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5681858-A | Cycloalkyl hydroxyureas | PFIZER INC. (US) | 1997-10-28 | — | — | US | disclosed |
| EP-0693054-A1 | CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994022814-A1 | CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |