SCHEMBL8707331

SCHEMBL8707331

CC(=O)Oc1cc(C)ccc1C1CC(=O)NC2=CC[C@H]3[C@@H]4CCC[C@@]4(C)CC[C@@H]3[C@]21C

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SHBG P04278 1/20 0.33
CYP19A1 P11511 4/20 0.32
STS P08842 1/20 0.31
AR P10275 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
DDB1 Q16531 1/20 0.30
CRBN Q96SW2 1/20 0.30
MBOAT4 Q96T53 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8707336 0.74 MBOAT4 (0.39) SHBGCYP19A1CYP3A4MBOAT4
SCHEMBL7611435 0.71 MBOAT4 (0.33) STSMBOAT4
SCHEMBL8080471 0.68 MBOAT4 (0.34) CYP19A1MBOAT4
SCHEMBL5183889 0.66 SRD5A1 (0.53) CYP19A1
SCHEMBL5183886 0.66 SRD5A1 (0.53) CYP19A1
SCHEMBL8710300 0.63 CYP19A1 (0.40) CYP19A1CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL7475323 0.62 TDP1 (0.44) CYP19A1CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL8707384 0.62 TDP1 (0.49) CYP19A1ARCYP3A4CYP2C9CYP2C19
SCHEMBL10738737 0.62 LMNA (0.46)
SCHEMBL1902709 0.61 CYP19A1 (0.40) CYP19A1MBOAT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0880540-A1 17-BETA-CYCLOPROPYL(AMINO/OXY) 4-AZA STEROIDS AS ACTIVE INHIBITORS OF TESTOSTERONE 5-ALPHA-REDUCTASE AND C17-20-LYASE HOECHST MARION ROUSSEL, INC. (US) 1998-12-02 EP disclosed
WO-1997030069-A1 17-BETA-CYCLOPROPYL(AMINO/OXY) 4-AZA STEROIDS AS ACTIVE INHIBITORS OF TESTOSTERONE 5-ALPHA-REDUCTASE AND C17-20-LYASE HOECHST MARION ROUSSEL, INC. (US) 1997-08-21 WO disclosed