Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 4/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 13/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8703515 | 1.00 | EPHA2 (0.49) | EPHA2NR1H4ABCB1DRD2HTR1A | |
| SCHEMBL8702892 | 1.00 | EPHA2 (0.49) | EPHA2NR1H4ABCB1DRD2HTR1A | |
| SCHEMBL8702860 | 0.90 | NR1H4 (0.49) | EPHA2NR1H4ERBB2EPHB4TSHR | |
| SCHEMBL8704689 | 0.90 | NR1H4 (0.49) | EPHA2NR1H4ERBB2EPHB4TSHR | |
| SCHEMBL8702864 | 0.90 | NR1H4 (0.49) | EPHA2NR1H4ERBB2EPHB4TSHR | |
| SCHEMBL27340482 | 0.89 | EPHA2 (0.53) | EPHA2NR1H4ERBB2EPHB4 | |
| SCHEMBL9068236 | 0.86 | SLC2A1 (0.51) | ABCB1DRD2HTR1ATP53CYP3A4 | |
| SCHEMBL9068232 | 0.86 | SLC2A1 (0.51) | ABCB1DRD2HTR1ATP53CYP3A4 | |
| SCHEMBL8702698 | 0.85 | TP53 (0.49) | ABCB1DRD2HTR1ATP53CYP3A4 | |
| SCHEMBL8709905 | 0.85 | TP53 (0.49) | ABCB1DRD2HTR1ATP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1044365-C | Alpha, omega-diarylalkane derivatives, their preparation and their use in the treatment and prevention of circulatory diseases and psychosis | SANKYO CO (JP) | 1999-07-28 | — | — | CN | disclosed |
| EP-0844000-A1 | Use of alpha, omega-diarylalkane derivatives in the treatment and prevention of psychosis | SANKYO COMPANY LIMITED (JP) | 1998-05-27 | — | — | EP | disclosed |
| US-5556864-A | TREATMENT OF CIRCULATORY DISEASES AND PSYCHOSIS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| CN-1102640-A | Alpha, omega-diarylalkane derivatives, their preparation and their use in the treatment and prevention of circulatory and psychiatric disorders | SANKYO CO (JP) | 1995-05-17 | — | — | CN | disclosed |
| EP-0600717-A1 | Phenoxyalkylamines, -pyrrolidines and -piperidines for the treatment and prevention of circulatory diseases and psychosis | SANKYO COMPANY LIMITED (JP) | 1994-06-08 | — | — | EP | disclosed |