Bromide

Bromide

SCHEMBL8707683

Br.NC(N)=Nc1nc(CBr)cs1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
ATP4A P20648 16/20 0.46
ATP4B P51164 16/20 0.46
SLC22A2 O15244 2/20 0.46
CA12 O43570 2/20 0.46
SLC22A3 O75751 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
LMNA P02545 2/20 0.46
TSHR P16473 2/20 0.46
MAOA P21397 2/20 0.46
CA4 P22748 2/20 0.46
CA6 P23280 2/20 0.46
HRH2 P25021 2/20 0.46
CA5A P35218 2/20 0.46
CA7 P43166 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8708729 0.98 CYP1A2 (0.49) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL5879530 0.81 CYP1A2 (0.50) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL10776417 0.80 SLC22A2 (0.50) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL18197976 0.79 CYP1A2 (0.48) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL18346920 0.79 HRH2 (0.56) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
Hydrochloric Acid SCHEMBL8934520 0.79 SLC22A2 (0.49) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL18197974 0.77 CYP2D6 (0.47) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL22296554 0.76 HRH2 (0.53) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL12592706 0.75 CYP2D6 (0.45) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2
SCHEMBL16386211 0.75 CYP2D6 (0.45) CYP1A2CYP2D6CYP2C9CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1998040367-A1 NOVEL THIAZOLE DERIVATIVES AND THEIR PREPARATION ALBEMARLE CORPORATION (US) 1998-09-17 WO claimed