Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.33 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | DUT | P33316 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1401064 | 0.89 | TP53 (0.38) | FKBP1ADUT | |
| SCHEMBL24795958 | 0.89 | TP53 (0.38) | FKBP1ADUT | |
| SCHEMBL28523662 | 0.86 | FKBP1A (0.35) | FKBP1ATOP2ADUT | |
| SCHEMBL3750168 | 0.86 | FKBP1A (0.35) | FKBP1ATOP2ADUT | |
| SCHEMBL959880 | 0.85 | FKBP1A (0.34) | FKBP1ADUT | |
| SCHEMBL963144 | 0.81 | FKBP1A (0.32) | FKBP1ADUT | |
| SCHEMBL8712263 | 0.80 | PLA2G10 (0.37) | PLA2G10PLA2G5ALDH1A1KDM4E | |
| SCHEMBL8712367 | 0.80 | PLA2G10 (0.34) | PLA2G10PLA2G5ALDH1A1KDM4E | |
| SCHEMBL625416 | 0.80 | CHRM2 (0.35) | FKBP1AALDH1A1TOP2ADUT | |
| SCHEMBL958204 | 0.80 | CHRM2 (0.35) | FKBP1AALDH1A1TOP2ADUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736549-A | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE, USED FOR TREATING OR PREVENTING TISSUE REJECTION OR SELECTIVE SUPPRESSION OF MAMMALIAN T-CELL FUNCTION | CHIROSCIENCE LIMITED (GB) | 1998-04-07 | — | — | US | disclosed |
| WO-1996011200-A1 | PURINE AND GUANINE COMPOUNDS AS INHIBITORS OF PNP | CHIROSCIENCE LIMITED (GB) | 1996-04-18 | — | — | WO | disclosed |