Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.37 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705973 | 0.87 | PLA2G10 (0.39) | PLA2G10PLA2G5KDM4EALDH1A1CHRM2 | |
| SCHEMBL8712367 | 0.82 | PLA2G10 (0.34) | PLA2G10PLA2G5KDM4EALDH1A1CCKBR | |
| SCHEMBL24726898 | 0.82 | PLA2G10 (0.39) | PLA2G10PLA2G5KDM4EALDH1A1CHRM2 | |
| SCHEMBL782927 | 0.82 | CHRM2 (0.40) | PLA2G10PLA2G5KDM4EALDH1A1CHRM2 | |
| SCHEMBL8708692 | 0.80 | FKBP1A (0.35) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL18212788 | 0.80 | PLA2G10 (0.36) | PLA2G10PLA2G5NR1H2KDM4EALDH1A1 | |
| SCHEMBL18204610 | 0.79 | PLA2G10 (0.42) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL17951050 | 0.79 | PLA2G10 (0.42) | PLA2G10PLA2G5KDM4EALDH1A1 | |
| SCHEMBL9383235 | 0.78 | PLA2G10 (0.39) | PLA2G10PLA2G5KDM4EALDH1A1CHRM2 | |
| SCHEMBL9382253 | 0.78 | PLA2G10 (0.39) | PLA2G10PLA2G5KDM4EALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5736549-A | INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE, USED FOR TREATING OR PREVENTING TISSUE REJECTION OR SELECTIVE SUPPRESSION OF MAMMALIAN T-CELL FUNCTION | CHIROSCIENCE LIMITED (GB) | 1998-04-07 | — | — | US | disclosed |
| WO-1996011200-A1 | PURINE AND GUANINE COMPOUNDS AS INHIBITORS OF PNP | CHIROSCIENCE LIMITED (GB) | 1996-04-18 | — | — | WO | disclosed |