SCHEMBL8709166

SCHEMBL8709166

Nc1ncnc2c1ncn2COC(CO)OCP(=O)(O)O.[NaH].[NaH]

nearest known ligand 0.65

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.65
FGFR1 P11362 1/20 0.60
SLC22A6 Q4U2R8 1/20 0.60
ENPP1 P22413 1/20 0.54
ADORA2A P29274 4/20 0.51
AHCY P23526 3/20 0.51
ADORA1 P30542 2/20 0.49
CYP2D6 P10635 6/20 0.47
ALDH1A1 P00352 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8897633 0.99 CYP3A4 (0.67) CYP3A4FGFR1SLC22A6ENPP1ADORA2A
SCHEMBL8709179 0.98 CYP3A4 (0.65) CYP3A4FGFR1SLC22A6ENPP1ADORA2A
SCHEMBL8895953 0.89 CYP3A4 (0.54) CYP3A4FGFR1SLC22A6ENPP1ADORA2A
SCHEMBL385752 0.83 CYP3A4 (0.73) CYP3A4FGFR1SLC22A6ADORA2AAHCY
SCHEMBL66563 0.83 CYP3A4 (0.73) CYP3A4FGFR1SLC22A6ADORA2AAHCY
SCHEMBL29437221 0.83 CYP3A4 (0.73) CYP3A4FGFR1SLC22A6ADORA2AAHCY
SCHEMBL10670033 0.81 FGFR1 (0.65) CYP3A4FGFR1SLC22A6ENPP1ADORA2A
Pyrophosphoric Acid SCHEMBL10602251 0.81 CYP3A4 (0.55) CYP3A4FGFR1SLC22A6ENPP1ADORA2A
Tenofovir Anhydrous SCHEMBL27825238 0.81 CYP3A4 (0.98) CYP3A4CYP2D6
SCHEMBL8927904 0.80 SLC22A6 (0.70) CYP3A4FGFR1SLC22A6ENPP1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5688778-A VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-18 US claimed
US-5837871-A PHOSPHONATE DERIVATIVES; ANTITUMOR AGENTS, VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-11-17 US disclosed
US-5726174-A VIRICIDES, ANTITUMOR AGENTS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1998-03-10 US disclosed
US-5696265-A ANTIRETROVIRAL; ANTITUNOR AGENT INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-09 US disclosed
US-5693798-A ACTIVE AGAINST RETROVIRAL DISEASES; PROPHYLAXIS INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-12-02 US disclosed
US-5688778-A VIRICIDES INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-18 US disclosed
US-5686611-A Nucleoside analogs INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) 1997-11-11 US disclosed