Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 17/20 | 0.58 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 5/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8931446 | 0.89 | MMP13 (0.61) | MMP13FDFT1MMP2 | |
| SCHEMBL8931458 | 0.88 | MMP13 (0.59) | MMP13FDFT1MMP2MMP12 | |
| SCHEMBL8772621 | 0.83 | MMP13 (0.60) | MMP13FDFT1MMP2MMP12 | |
| SCHEMBL3259548 | 0.82 | MMP13 (0.63) | MMP13FDFT1MMP2MMP12 | |
| SCHEMBL8931430 | 0.82 | MMP13 (0.66) | MMP13FDFT1MMP2MMP12 | |
| SCHEMBL8772700 | 0.80 | MMP13 (0.86) | MMP13FDFT1MMP2MMP12 | |
| SCHEMBL8593465 | 0.79 | MMP13 (0.57) | MMP13FDFT1MMP2 | |
| SCHEMBL8593082 | 0.78 | MMP13 (0.50) | MMP13FDFT1MMP2 | |
| SCHEMBL8592665 | 0.78 | MMP13 (0.53) | MMP13FDFT1MMP2MMP12 | |
| SCHEMBL8590121 | 0.76 | FDFT1 (0.53) | MMP13FDFT1MMP2MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654315-A | ENZYME INHIBITORS AS ANTICHOLESTEROL AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1997-08-05 | — | — | US | claimed |
| EP-0626960-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-12-07 | — | — | EP | claimed |
| US-5770608-A | ANTICHOLESTEROL AGENTS FOR TREATING CARDIOVASCULAR DISORDERS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1998-06-23 | — | — | US | disclosed |
| US-5654315-A | ENZYME INHIBITORS AS ANTICHOLESTEROL AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1997-08-05 | — | — | US | disclosed |
| WO-1993013096-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-07-08 | — | — | WO | disclosed |