Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 10/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710343 | 1.00 | GRIN1 (0.44) | GRIN1GRIN2BFFAR1CA12CA1 | |
| SCHEMBL20266970 | 0.81 | SLC6A2 (0.52) | GRIN1GRIN2BFFAR1 | |
| SCHEMBL16685958 | 0.80 | NAAA (0.49) | MAPTSMN1; SMN2MAOB | |
| SCHEMBL21404962 | 0.78 | GRIN1 (0.44) | GRIN1GRIN2BHRH3 | |
| SCHEMBL21404961 | 0.78 | GRIN1 (0.44) | GRIN1GRIN2BHRH3 | |
| SCHEMBL16838744 | 0.73 | SMN1; SMN2 (0.56) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8710414 | 0.72 | ALDH1A1 (0.45) | GRIN1GRIN2BCA12CA1CA2 | |
| SCHEMBL8710412 | 0.72 | ALDH1A1 (0.45) | GRIN1GRIN2BCA12CA1CA2 | |
| SCHEMBL31434565 | 0.71 | FURIN (0.41) | TDP1HRH3CYP3A4 | |
| SCHEMBL31434568 | 0.71 | FURIN (0.41) | TDP1HRH3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693054-B1 | CYCLOALKYLHYDROXYUREAS AND THEIR USE AS LIPOXYGENASE INHIBITORS | PFIZER (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5681858-A | Cycloalkyl hydroxyureas | PFIZER INC. (US) | 1997-10-28 | — | — | US | disclosed |