Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1247788 | 0.82 | HPGD (0.47) | SMN1; SMN2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL12892338 | 0.81 | NR4A1 (0.49) | SMN1; SMN2ALDH1A1ALOX15TSHRPOLB | |
| SCHEMBL1250161 | 0.73 | KDM4E (0.46) | RXFP1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6570236 | 0.73 | MAPT (0.36) | ALDH1A1KDM4EHPGDHSD17B10POLB | |
| SCHEMBL8049848 | 0.72 | ALDH1A1 (0.44) | SMN1; SMN2NPSR1ALDH1A1KDM4EHPGD | |
| SCHEMBL12892330 | 0.72 | ALDH1A1 (0.42) | SMN1; SMN2NPSR1ALDH1A1KDM4EALOX15 | |
| SCHEMBL9427611 | 0.72 | TDP1 (0.54) | SMN1; SMN2NPSR1PRNPRXFP1ALDH1A1 | |
| SCHEMBL9750203 | 0.70 | TSHR (0.50) | RXFP1ALDH1A1HPGDTSHRKMT2A | |
| SCHEMBL26126699 | 0.69 | CACNA2D1 (0.44) | SMN1; SMN2NPSR1ALDH1A1KDM4EHPGD | |
| SCHEMBL4210492 | 0.68 | MAPT (0.57) | SMN1; SMN2NPSR1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |