Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710118 | 0.91 | GAA (0.39) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL8710560 | 0.86 | MAPT (0.44) | ALDH1A1KDM4EGAAMAPTLMNA | |
| SCHEMBL8704453 | 0.83 | GAA (0.40) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL8710310 | 0.82 | GAA (0.56) | ALDH1A1KDM4EGAAMAPTLMNA | |
| SCHEMBL1685239 | 0.81 | GAA (0.56) | ALDH1A1KDM4EGAAHSD17B10MAPT | |
| SCHEMBL29612322 | 0.78 | MAPT (0.49) | ALDH1A1KDM4EGAAUSP2HSD17B10 | |
| SCHEMBL9191296 | 0.78 | GAA (0.64) | ALDH1A1KDM4EGAAUSP2HSD17B10 | |
| SCHEMBL8804803 | 0.77 | GAA (0.49) | ALDH1A1KDM4EGAAMAPTL3MBTL1 | |
| SCHEMBL8705661 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4EGAAMAPTL3MBTL1 | |
| SCHEMBL8710767 | 0.75 | GAA (0.53) | ALDH1A1GAAMAPTLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5717112-A | Benzofuranone and benzodifuranone compounds | ZENECA LIMITED (GB) | 1998-02-10 | — | — | US | disclosed |
| EP-0669922-B1 | BENZOFURANONES, BENZODIFURANTRIONES AND PROCESSES FOR THE PREPARATION OF BENZODIFURANDIONES | BASF AG (DE) | 1997-08-20 | — | — | EP | disclosed |
| US-5625080-A | Benzodifurantrione compounds and process | ZENECA LIMITED (GB) | 1997-04-29 | — | — | US | disclosed |
| EP-0669922-A1 | BENZOFURANONE AND BENZODIFURANTRIONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF BENZODIFURANONES. | ZENECA LTD (GB) | 1995-09-06 | — | — | EP | disclosed |
| WO-1994012501-A1 | BENZOFURANONE AND BENZODIFURANTRIONE DERIVATIVES AND PROCESS FOR THE PREPARATION OF BENZODIFURANONES | ZENECA LIMITED (GB) | 1994-06-09 | — | — | WO | disclosed |