Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.71 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.65 |
| ▸ | AR | P10275 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10123281 | 1.00 | SIGMAR1 (0.71) | SIGMAR1HRH3ARTSHRMEN1 | |
| SCHEMBL10123280 | 0.85 | SIGMAR1 (0.76) | SIGMAR1HRH3 | |
| SCHEMBL870758 | 0.85 | SIGMAR1 (0.76) | SIGMAR1HRH3 | |
| SCHEMBL776259 | 0.85 | HRH3 (0.64) | SIGMAR1HRH3 | |
| SCHEMBL15314418 | 0.83 | SIGMAR1 (0.73) | SIGMAR1HRH3ARTSHRMEN1 | |
| SCHEMBL15314413 | 0.83 | SIGMAR1 (0.73) | SIGMAR1HRH3ARTSHRMEN1 | |
| SCHEMBL12883193 | 0.81 | HRH3 (0.72) | SIGMAR1HRH3ARTSHRMEN1 | |
| SCHEMBL12836573 | 0.81 | HRH3 (0.72) | SIGMAR1HRH3ARTSHRMEN1 | |
| SCHEMBL11084414 | 0.81 | SIGMAR1 (0.67) | SIGMAR1HRH3ARTSHRMEN1 | |
| SCHEMBL11084417 | 0.81 | SIGMAR1 (0.67) | SIGMAR1HRH3ARTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | NATIONAL SCIENCE FOUNDATION | 2012-03-29 | — | — | US | disclosed |
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | NATIONAL SCIENCE FOUNDATION | 2012-03-29 | — | — | US | disclosed |
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | NATIONAL SCIENCE FOUNDATION | 2012-03-29 | — | — | US | disclosed |
| WO-2010094029-A2 | ASYMMETRIC CYCLOPROPANATION WITH SUCCINIMIDYL DIAZOACETATE | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010094029-A2 | ASYMMETRIC CYCLOPROPANATION WITH SUCCINIMIDYL DIAZOACETATE | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077959-A1 | Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate | SI, STOM, SUCLA2 | SIGMAR1 4290/4885HRH3 2036/4885AR 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.