Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713547 | 0.85 | NPC1 (0.41) | NPC1RAB9AMAPTNPSR1TLR9 | |
| SCHEMBL8050789 | 0.73 | CBFB (0.40) | NPC1RAB9AMAPTNPSR1TLR9 | |
| SCHEMBL8051875 | 0.73 | MAPK8 (0.39) | NPC1RAB9AMAPTNPSR1TLR9 | |
| SCHEMBL8044151 | 0.71 | ALDH1A1 (0.44) | NPC1RAB9AMAPTNPSR1TLR9 | |
| SCHEMBL8042924 | 0.70 | MAPT (0.52) | NPC1RAB9AMAPTNPSR1TLR9 | |
| SCHEMBL8712843 | 0.69 | MAPK8 (0.42) | NPC1RAB9AMAPTNPSR1TLR9 | |
| SCHEMBL8044153 | 0.69 | MAPT (0.51) | NPC1RAB9AMAPTNPSR1TLR9 | |
| SCHEMBL8042820 | 0.69 | MAPK8 (0.48) | NPC1RAB9AMAPTNPSR1TLR9 | |
| SCHEMBL8711276 | 0.69 | RAB9A (0.38) | NPC1RAB9AMAPTNPSR1TLR9 | |
| SCHEMBL8044319 | 0.68 | MAPT (0.45) | NPC1RAB9AMAPTNPSR1TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |