Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 8/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050210 | 0.75 | HTR1A (0.48) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8710131 | 0.74 | HTR1A (0.39) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL3597116 | 0.71 | SREBF2 (0.57) | RAB9AALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL13545609 | 0.71 | SREBF2 (0.57) | RAB9AALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL8710649 | 0.71 | HCAR2 (0.37) | — | |
| SCHEMBL8715968 | 0.68 | MAPK8 (0.47) | RAB9AHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL8050637 | 0.67 | HDAC6 (0.49) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8032700 | 0.66 | HTR1A (0.49) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL13545613 | 0.65 | KDM4E (0.54) | RAB9AALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL4047725 | 0.65 | HTR1A (0.58) | HTR1AHTR2AHTR7RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |