Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050293 | 0.86 | RAB9A (0.42) | RAB9AALDH1A1SMN1; SMN2NPC1KMT2A | |
| SCHEMBL8710822 | 0.75 | HTR1A (0.39) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8710131 | 0.74 | HTR1A (0.39) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL10613520 | 0.73 | RAB9A (0.60) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8051506 | 0.72 | ALDH1A1 (0.53) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL4127796 | 0.71 | RAB9A (0.57) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL4047725 | 0.71 | HTR1A (0.58) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL9334806 | 0.71 | RAB9A (0.57) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8047174 | 0.71 | RAB9A (0.47) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL452473 | 0.70 | ALDH1A1 (0.35) | HTTALDH1A1SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |