Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.80 |
| ▸ | MAPT | P10636 | 7/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.80 |
| ▸ | MEN1 | O00255 | 5/20 | 0.80 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | MITF | O75030 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | ATM | Q13315 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 2/20 | 0.56 |
| ▸ | CASP2 | P42575 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16728064 | 0.88 | KMT2A (0.74) | RAB9AMAPTKMT2AMEN1NPC1 | |
| SCHEMBL29145506 | 0.87 | MEN1 (0.74) | RAB9AMAPTKMT2AMEN1NPC1 | |
| SCHEMBL29145514 | 0.86 | RAB9A (0.72) | RAB9AMAPTKMT2AMEN1NPC1 | |
| SCHEMBL23898948 | 0.84 | KMT2A (0.83) | RAB9AMAPTKMT2AMEN1NPC1 | |
| SCHEMBL9134339 | 0.84 | KMT2A (0.83) | RAB9AMAPTKMT2AMEN1NPC1 | |
| SCHEMBL8572381 | 0.84 | KMT2A (0.83) | RAB9AMAPTKMT2AMEN1NPC1 | |
| SCHEMBL12406969 | 0.83 | KMT2A (0.71) | RAB9AMAPTKMT2AMEN1NPC1 | |
| SCHEMBL20313717 | 0.83 | KMT2A (0.71) | RAB9AMAPTKMT2AMEN1NPC1 | |
| SCHEMBL8713449 | 0.83 | KMT2A (0.71) | RAB9AMAPTKMT2AMEN1NPC1 | |
| SCHEMBL1249138 | 0.82 | KMT2A (0.63) | RAB9AMAPTKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |