Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.71 |
| ▸ | MEN1 | O00255 | 7/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.71 |
| ▸ | NPC1 | O15118 | 6/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | MITF | O75030 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 9/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | XBP1 | P17861 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | MMP2 | P08253 | 2/20 | 0.60 |
| ▸ | MMP9 | P14780 | 2/20 | 0.60 |
| ▸ | MMP8 | P22894 | 2/20 | 0.60 |
| ▸ | MMP13 | P45452 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12406969 | 1.00 | KMT2A (0.71) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL20313717 | 1.00 | KMT2A (0.71) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL8572381 | 0.92 | KMT2A (0.83) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL9134339 | 0.92 | KMT2A (0.83) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL23898948 | 0.92 | KMT2A (0.83) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL9137742 | 0.87 | KMT2A (0.71) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL24291388 | 0.87 | MAPT (0.74) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL9137298 | 0.87 | KMT2A (0.71) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL24213121 | 0.87 | KMT2A (0.76) | KMT2AMEN1RAB9ANPC1POLB | |
| SCHEMBL16367722 | 0.87 | KMT2A (0.76) | KMT2AMEN1RAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682931-B2 | Aryloyl(oxy or amino)pentafluorosulfanylbenzene compound, pharmaceutically acceptable salt thereof, and prodrugs thereof | UBE INDUSTRIES, LTD. (JP) | 2017-06-20 | — | — | US | disclosed |
| US-20160244407-A1 | ARYLOYL(OXY OR AMINO)PENTAFLUOROSULFANYLBENZENE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PRODRUGS THEREOF | UBE INDUSTRIES, LTD. (JP) | 2016-08-25 | — | — | US | disclosed |
| US-9134328-B2 | Methods of using benzothiazole derivative compounds and compositions | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-09-15 | — | — | US | disclosed |
| US-8927584-B2 | Synthesis of 2-(4-aminophenyl)benzothiazole derivatives and use thereof | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2015-01-06 | — | — | US | disclosed |
| US-8895313-B2 | Ligands for aggregated tau molecules | WISTA LABORATORIES LTD. (SG) | 2014-11-25 | — | — | US | disclosed |
| US-20140220590-A1 | METHODS OF USING BENZOTHIAZOLE DERIVATIVE COMPOUNDS AND COMPOSITIONS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140046290-A1 | SYNTHESIS OF 2-(4-AMINOPHENYL)BENZOTHIAZOLE DERIVATIVES AND USE THEREOF | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2014-02-13 | — | — | US | disclosed |
| US-8592603-B2 | Synthesis of 2-(4-aminophenyl) benzothiazole derivatives and use thereof | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2013-11-26 | — | — | US | disclosed |
| US-8580229-B2 | Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2013-11-12 | — | — | US | disclosed |
| US-20130045164-A1 | AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2013-02-21 | — | — | US | disclosed |
| US-8343457-B2 | Amyloid imaging as a surrogate marker for efficacy of anti-amyloid therapies | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2013-01-01 | — | — | US | disclosed |
| US-20120215154-A1 | SYNTHESIS OF 2-(4-AMINOPHENYL) BENZOTHIAZOLE DERIVATIVES AND USE THEREOF | KAOHSIUNG MEDICAL UNIVERSITY (TW) | 2012-08-23 | — | — | US | disclosed |
| US-8236282-B2 | Benzothiazole derivative compounds, compositions and uses | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2012-08-07 | — | — | US | disclosed |
| US-20120177572-A1 | AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES | UNIVERSITY OF PITTSBURGH- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-07-12 | — | — | US | disclosed |
| US-20110171739-A1 | LIGANDS FOR AGGREGATED TAU MOLECULES | WISTA LABORATORIES LTD. | 2011-07-14 | — | — | US | disclosed |
| US-20100021388-A1 | BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2010-01-28 | — | — | US | disclosed |
| US-20080190855-A1 | removing toxic heavy metal ions from water for drinking water filtration or environmental cleanup; carbon attached directly to the amino acid via carboxyl groups on the surface; converting surface carboxyl groups to acyl halide groups and then contacting with amino acid; carbon electrode; graphite powder | ISIS INNOVATION LIMITED (GB) | 2008-08-14 | — | — | US | disclosed |
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |
| US-4447515-A | DIACYLAMINE COMPOUND ADDED | FUJI PHOTO FILM CO., LTD. (JP) | 1984-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080190855-A1 | removing toxic heavy metal ions from water for drinking water filtration or environmental cleanup; carbon attached directly to the amino acid via carboxyl groups on the surface; converting surface carboxyl groups to acyl halide groups and then contacting with amino acid; carbon electrode; graphite powder | GLUL, SLC3A2, ARGLU1 | KMT2A 930/4885MEN1 4371/4885RAB9A 603/4885 |
| US-20110171739-A1 | LIGANDS FOR AGGREGATED TAU MOLECULES | MAPT, PRNP, MAP4 | KMT2A 3452/4885MEN1 3205/4885RAB9A 2622/4885 |
| US-20120177572-A1 | AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES | TTR, APP, SAAL1 | KMT2A 4494/4885MEN1 582/4885RAB9A 3270/4885 |
| US-20130045164-A1 | AMYLOID IMAGING AS A SURROGATE MARKER FOR EFFICACY OF ANTI-AMYLOID THERAPIES | TTR, APP, SAAL1 | KMT2A 4494/4885MEN1 582/4885RAB9A 3270/4885 |
| US-20100021388-A1 | BENZOTHIAZOLE DERIVATIVE COMPOUNDS, COMPOSITIONS AND USES | APP, MAPT, PSEN1 | KMT2A 2493/4885MEN1 1105/4885RAB9A 4158/4885 |
| US-20140046290-A1 | SYNTHESIS OF 2-(4-AMINOPHENYL)BENZOTHIAZOLE DERIVATIVES AND USE THEREOF | CCNT1, PPOX, TPT1 | KMT2A 2192/4885MEN1 1141/4885RAB9A 2984/4885 |
| US-20120215154-A1 | SYNTHESIS OF 2-(4-AMINOPHENYL) BENZOTHIAZOLE DERIVATIVES AND USE THEREOF | HCCS, PAH, PPOX | KMT2A 627/4885MEN1 1027/4885RAB9A 4265/4885 |
| US-20160244407-A1 | ARYLOYL(OXY OR AMINO)PENTAFLUOROSULFANYLBENZENE COMPOUND, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PRODRUGS THEREOF | SLCO1B1, SLCO2B1, SLCO1B3 | KMT2A 1810/4885MEN1 4343/4885RAB9A 793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.