SCHEMBL8711826

SCHEMBL8711826

O=C(N[C@@H](Cc1ccccc1)C(=O)OC(=O)[C@H](Cc1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc21)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.71

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ MDM4 O15151 2/20 0.53
▸ TP53 P04637 2/20 0.53
▸ CASP3 P42574 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ EPHX2 P34913 1/20 0.47
▸ HDAC1 Q13547 1/20 0.46
▸ HDAC2 Q92769 1/20 0.46
▸ PTPN1 P18031 1/20 0.46
▸ TNF P01375 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12531899 0.91 ATM (0.53) MDM4TP53CASP3TNF
SCHEMBL29401932 0.91 ATM (0.53) MDM4TP53CASP3TNF
SCHEMBL13743302 0.91 ATM (0.53) MDM4TP53CASP3TNF
SCHEMBL2977877 0.91 ATM (0.53) MDM4TP53CASP3TNF
SCHEMBL29440768 0.91 MDM4 (0.59) MDM4TP53CASP3KMT2ATNF
SCHEMBL119455 0.91 MDM4 (0.59) MDM4TP53CASP3KMT2ATNF
SCHEMBL29367434 0.91 MDM4 (0.59) MDM4TP53CASP3KMT2ATNF
SCHEMBL1228254 0.91 MDM4 (0.59) MDM4TP53CASP3KMT2ATNF
SCHEMBL118169 0.91 MDM4 (0.59) MDM4TP53CASP3KMT2ATNF
SCHEMBL29398498 0.91 MDM4 (0.59) MDM4TP53CASP3KMT2ATNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014153624-A1 ANTIBACTERIAL COMPOUNDS THE UNIVERSITY OF SYDNEY (AU) 2014-10-02 — — WO disclosed
EP-0474506-B1 Antimicrobial peptides MORINAGA MILK INDUSTRY CO LTD (JP) 1998-05-13 — — EP disclosed
EP-0629213-B1 USE OF AN IMMUNOSTIMULATORY AGENT MORINAGA MILK INDUSTRY CO LTD (JP) 1996-10-23 — — EP disclosed
US-5466669-A Polypeptides MORINAGA MILK INDUSTRY CO., LTD. (JP) 1995-11-14 — — US disclosed
EP-0629213-A1 IMMUNOSTIMULATORY AGENT. MORINACA MILK INDUSTRY CO LTD (JP) 1994-12-21 — — EP disclosed
US-5304633-A Polypeptides MORINAGA MILK INDUSTRY CO., LTD. (JP) 1994-04-19 — — US disclosed
WO-1993018061-A1 IMMUNOSTIMULATORY AGENT MORINAGA MILK INDUSTRY CO., LTD. (JP) 1993-09-16 — — WO disclosed
EP-0474506-A1 Antimicrobial peptides MORINAGA MILK INDUSTRY CO., LTD. (JP) 1992-03-11 — — EP disclosed
US-4753985-A Synthesis of organic compounds using deformable gel in porous rigid support UNITED KINGDOM ATOMIC ENERGY AUTHORITY (GB) 1988-06-28 — — US disclosed
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