SCHEMBL8712176

SCHEMBL8712176

O=C(c1cc(Br)ccc1O)c1ncccc1O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTA1 P08263 3/20 0.63
CYP1A2 P05177 1/20 0.62
CYP2C9 P11712 1/20 0.62
HPGD P15428 1/20 0.62
ALOX15 P16050 1/20 0.62
CASP1 P29466 1/20 0.62
CYP2C19 P33261 1/20 0.62
CES2 O00748 1/20 0.53
GALR3 O60755 1/20 0.53
MAPT P10636 3/20 0.52
KDM4E B2RXH2 2/20 0.52
ALDH1A1 P00352 1/20 0.52
HSP90AA1 P07900 1/20 0.52
NPSR1 Q6W5P4 1/20 0.52
TLR7 Q9NYK1 1/20 0.50
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
OPRK1 P41145 2/20 0.47
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27489604 0.91 ALOX15 (0.59) GSTA1CYP1A2CYP2C9HPGDALOX15
SCHEMBL27443343 0.88 CYP1A2 (0.56) GSTA1CYP1A2CYP2C9HPGDALOX15
SCHEMBL8716457 0.86 CYP1A2 (0.53) GSTA1CYP1A2CYP2C9HPGDALOX15
SCHEMBL27445514 0.84 CYP1A2 (0.51) GSTA1CYP1A2CYP2C9HPGDALOX15
SCHEMBL27446633 0.84 HPGD (0.51) GSTA1CYP1A2CYP2C9HPGDALOX15
SCHEMBL27412364 0.84 CYP1A2 (0.51) GSTA1CYP1A2CYP2C9HPGDALOX15
SCHEMBL27440948 0.84 HPGD (0.51) GSTA1CYP1A2CYP2C9HPGDALOX15
SCHEMBL8709808 0.83 CSNK2A1 (0.50) GSTA1CYP1A2CYP2C9HPGDALOX15
SCHEMBL8713755 0.82 HPGD (0.49) GSTA1CYP1A2CYP2C9HPGDALOX15
SCHEMBL8713756 0.82 HPGD (0.49) GSTA1CYP1A2CYP2C9HPGDALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5716971-A FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-02-10 US disclosed
EP-0623597-B1 Pyridine derivatives, with potassium channel opening activity TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-10-22 EP disclosed
EP-0623597-A1 Pyridine derivatives, with potassium channel opening activity Takeda Chemical Industries, Ltd. (JP) 1994-11-09 EP disclosed