Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | COMT | P21964 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SPR | P35270 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8712176 | 0.83 | GSTA1 (0.63) | HPGDMAPTSPRKDM4EALDH1A1 | |
| SCHEMBL8709049 | 0.81 | MAPT (0.53) | HPGDHTTMAPTSPRKDM4E | |
| SCHEMBL8711999 | 0.81 | TRPA1 (0.42) | HPGDMAPTSPRKDM4EGSTA1 | |
| SCHEMBL8654976 | 0.80 | FTO (0.45) | COMTMAPTSPRKDM4EL3MBTL1 | |
| SCHEMBL8709073 | 0.80 | KDM4E (0.50) | HPGDHTTMAPTSPRKDM4E | |
| SCHEMBL8714018 | 0.79 | KDM4E (0.43) | HPGDMAPTSPRKDM4EL3MBTL1 | |
| SCHEMBL8709727 | 0.79 | KDM5A (0.44) | HPGDMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8772949 | 0.78 | TLR7 (0.56) | COMTLMNAALDH1A1GSTA1MEN1 | |
| SCHEMBL27699633 | 0.77 | FTO (0.55) | COMTMAPTSPRKDM4EL3MBTL1 | |
| SCHEMBL11500852 | 0.77 | CSNK2A1 (0.72) | CSNK2A1HPGDHTTMAPTSPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |