Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.62 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.62 |
| ▸ | STAT3 | P40763 | 2/20 | 0.59 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.55 |
| ▸ | TUBB | P07437 | 1/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.55 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12768028 | 0.85 | KEAP1 (0.81) | GAAKMT2AKEAP1NFE2L2SQSTM1 | |
| SCHEMBL5801345 | 0.83 | KMT2A (0.70) | GAAKMT2AKEAP1FFAR4ALDH1A1 | |
| SCHEMBL15840645 | 0.81 | ALDH1A1 (0.77) | GAAKMT2AFFAR4KDM4ETUBB4A | |
| SCHEMBL15770989 | 0.81 | KMT2A (0.68) | GAAKMT2AFFAR4ALDH1A1LMNA | |
| SCHEMBL4347737 | 0.81 | KMT2A (0.68) | GAAKMT2AKEAP1FFAR4LMNA | |
| SCHEMBL23555177 | 0.79 | KEAP1 (1.00) | GAAKMT2AKEAP1NFE2L2SQSTM1 | |
| SCHEMBL27995939 | 0.79 | KEAP1 (0.72) | GAAKMT2AKEAP1NFE2L2SQSTM1 | |
| SCHEMBL10143424 | 0.79 | KEAP1 (0.72) | GAAKMT2AKEAP1NFE2L2SQSTM1 | |
| SCHEMBL789616 | 0.79 | KEAP1 (0.72) | GAAKMT2AKEAP1NFE2L2SQSTM1 | |
| SCHEMBL31681263 | 0.78 | KMT2A (0.64) | GAAKMT2AFFAR4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |