Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 2/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622204 | 0.87 | TRPV1 (0.58) | DHODHTRPV1ALDH1A1 | |
| SCHEMBL3092862 | 0.87 | TRPV1 (0.58) | DHODHTRPV1ALDH1A1 | |
| SCHEMBL23802602 | 0.85 | TRPV1 (0.56) | DHODHKMT2AMAPK1TRPV1ALDH1A1 | |
| SCHEMBL8058501 | 0.85 | TRPV1 (0.56) | DHODHKMT2AMAPK1TRPV1ALDH1A1 | |
| SCHEMBL15246442 | 0.85 | TRPV1 (0.56) | DHODHKMT2AMAPK1TRPV1ALDH1A1 | |
| SCHEMBL8058497 | 0.85 | TRPV1 (0.56) | DHODHKMT2AMAPK1TRPV1ALDH1A1 | |
| SCHEMBL27733182 | 0.85 | TRPV1 (0.56) | DHODHKMT2AMAPK1TRPV1ALDH1A1 | |
| SCHEMBL30218691 | 0.84 | POLB (0.42) | DHODHKMT2ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL1018380 | 0.83 | DHODH (0.40) | DHODHMMP1MMP9MMP13STAT3 | |
| SCHEMBL1018381 | 0.83 | DHODH (0.40) | DHODHMMP1MMP9MMP13STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107298667-B | Method for synthesizing icaritin | 北京盛诺基医药科技股份有限公司 | 2020-09-08 | — | — | CN | claimed |
| CN-107216303-B | Synthesis method of fluccoladine | 北京盛诺基医药科技股份有限公司 | 2020-04-21 | — | — | CN | claimed |
| CN-107216302-B | Synthesis method of flucloratadine | 北京盛诺基医药科技股份有限公司 | 2020-02-21 | — | — | CN | claimed |
| CN-107216303-B | Synthesis method of fluccoladine | 北京盛诺基医药科技股份有限公司 | 2020-04-21 | — | — | CN | disclosed |
| EP-0613877-B1 | Preparation process of quinone derivative and intermediate for the preparation thereof | EISAI KAGAKU KK (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5686635-A | Tetrahydro-alkenyl-methanonaphthalene-5,8-dione derivatives | EISAI CHEMICAL CO., LTD. (JP) | 1997-11-11 | — | — | US | disclosed |
| US-5677471-A | Process for the preparation of quinone derivative | EISAI CHEMICAL CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |
| US-5476955-A | Process for the preparation of a quinone derivative | EISAI CHEMICAL CO., LTD. (JP) | 1995-12-19 | — | — | US | disclosed |
| EP-0613877-A1 | Preparation process of quinone derivative and intermediate for the preparation thereof | EISAI CHEMICAL CO., LTD. (JP) | 1994-09-07 | — | — | EP | disclosed |