Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713689 | 0.88 | GPR84 (0.62) | GPR84CHEK1NPC1DAOKDM4E | |
| Acetic Acid SCHEMBL31668831 | 0.75 | GPR84 (0.62) | GPR84KDM4EALDH1A1TDP1 | |
| SCHEMBL27042187 | 0.73 | — | — | |
| SCHEMBL9164438 | 0.73 | — | — | |
| SCHEMBL8367403 | 0.73 | — | — | |
| SCHEMBL28192196 | 0.72 | GPR84 (0.46) | GPR84KDM4EALDH1A1GAAMAPT | |
| SCHEMBL11504164 | 0.71 | GPR84 (0.44) | GPR84KDM4EALDH1A1 | |
| SCHEMBL1999263 | 0.70 | — | — | |
| SCHEMBL27856952 | 0.68 | GPR84 (0.46) | GPR84KDM4EALDH1A1GAAMAPT | |
| SCHEMBL27041685 | 0.68 | GPR84 (0.50) | GPR84CHEK1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873319-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997022596-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-06-26 | — | — | WO | disclosed |