Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31501478 | 0.91 | — | — | |
| SCHEMBL358697 | 0.91 | — | — | |
| Ammonia Solution, Strong SCHEMBL28843903 | 0.89 | TRPA1 (0.56) | TRPA1ALOX15TP53TDP1HSD17B10 | |
| Zinc Ion SCHEMBL27995538 | 0.86 | TRPA1 (0.54) | TRPA1ALOX15TP53TDP1HSD17B10 | |
| SCHEMBL28000806 | 0.84 | TRPA1 (0.52) | TRPA1ALOX15TP53TDP1HSD17B10 | |
| SCHEMBL8712907 | 0.83 | TRPA1 (0.42) | TRPA1ALOX15TP53TDP1HSD17B10 | |
| Bicarbonate SCHEMBL28018391 | 0.81 | CSNK2A1 (0.53) | TRPA1ALOX15TP53TDP1HSD17B10 | |
| Phosphoric Acid SCHEMBL28139982 | 0.81 | TRPA1 (0.48) | TRPA1ALOX15TP53TDP1HSD17B10 | |
| Phosphoric Acid SCHEMBL27970284 | 0.79 | TRPA1 (0.46) | TRPA1ALOX15TP53TDP1HSD17B10 | |
| SCHEMBL23259164 | 0.74 | TRPA1 (0.50) | TRPA1ALOX15TP53TDP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716971-A | FOR TREATMENT OF ANGINA PECTORIS AND HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| EP-0623597-B1 | Pyridine derivatives, with potassium channel opening activity | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| CN-1097741-A | Pyridine derivate, Preparation Method And The Use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | CN | disclosed |
| EP-0623597-A1 | Pyridine derivatives, with potassium channel opening activity | Takeda Chemical Industries, Ltd. (JP) | 1994-11-09 | — | — | EP | disclosed |