Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 9/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8718851 | 0.99 | HTR3A (0.44) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL8717365 | 0.97 | HTR3A (0.48) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL3411552 | 0.87 | KDM4E (0.47) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL8876610 | 0.85 | ELANE (0.51) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL8718634 | 0.85 | KDM4E (0.49) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL2078485 | 0.84 | HTR3A (0.46) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL21725181 | 0.82 | ELANE (0.54) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL719399 | 0.81 | ELANE (0.53) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL31429395 | 0.80 | CYP3A4 (0.44) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 | |
| SCHEMBL2077051 | 0.79 | ELANE (0.54) | HTR3AHTR3ESLC22A2HTR3BCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708105-B1 | 5-HT4 receptor agonists | NISSHIN FLOUR MILLING CO (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5684003-A | GASTROINTESTINAL DISORDERS OR ANTIULCER AGENTS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-11-04 | — | — | US | disclosed |
| EP-0708105-A1 | 5-HT4 receptor agonists | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1996-04-24 | — | — | EP | disclosed |