SCHEMBL8714008

SCHEMBL8714008

CCOC(=O)/C(=C/c1c(Cl)n(Cc2ccccc2)c2ccccc12)C(=O)NC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.48
KDM4E B2RXH2 3/20 0.48
NPSR1 Q6W5P4 2/20 0.48
MAPK1 P28482 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
ALDH1A1 P00352 4/20 0.44
POLB P06746 2/20 0.44
GAA P10253 2/20 0.44
LMNA P02545 4/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
NR1H4 Q96RI1 1/20 0.41
DHODH Q02127 1/20 0.41
TSHR P16473 2/20 0.40
USP2 O75604 1/20 0.40
TSPO P30536 1/20 0.40
PKM P14618 1/20 0.40
PLA2G2A P14555 1/20 0.40
GFER P55789 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8714011 1.00 MAPT (0.48) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714570 0.94 MAPT (0.46) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714568 0.94 MAPT (0.46) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8717821 0.91 MEN1 (0.47) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8717817 0.91 MEN1 (0.47) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714053 0.88 MAPT (0.47) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714057 0.88 MAPT (0.47) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714362 0.85 MAPT (0.46) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714193 0.85 ALDH1A1 (0.51) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714365 0.85 MAPT (0.46) MAPTKDM4ENPSR1MAPK1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0843660-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1998-05-27 EP claimed
WO-1997005109-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1997-02-13 WO claimed
EP-0843660-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1998-05-27 EP disclosed
US-5696148-A POTENT ANTAGONIST OF METABOTROPIC GLUTAMATE RECEPTORS; TREATING EPILEPSY, PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, BRAIN DISORDER AND ALZHEIMER'S DISEASE NOVO NORDISK A/S (DK) 1997-12-09 US disclosed
WO-1997005109-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1997-02-13 WO disclosed