SCHEMBL8714570

SCHEMBL8714570

CCOC(=O)C(=Cc1c(Cl)n(Cc2ccc(Cl)cc2)c2ccccc12)C(=O)NC

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.46
KDM4E B2RXH2 3/20 0.46
NPSR1 Q6W5P4 3/20 0.46
MAPK1 P28482 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
ALDH1A1 P00352 4/20 0.46
LMNA P02545 4/20 0.46
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
USP2 O75604 1/20 0.46
POLB P06746 1/20 0.46
ALOX5 P09917 1/20 0.42
PTGES2 Q9H7Z7 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HTT P42858 1/20 0.41
MDM2 Q00987 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8714568 1.00 MAPT (0.46) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714008 0.94 MAPT (0.48) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714011 0.94 MAPT (0.48) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714193 0.92 ALDH1A1 (0.51) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8717817 0.92 MEN1 (0.47) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8717821 0.92 MEN1 (0.47) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714564 0.88 ALDH1A1 (0.47) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714561 0.88 ALDH1A1 (0.47) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714362 0.83 MAPT (0.46) MAPTKDM4ENPSR1MAPK1L3MBTL1
SCHEMBL8714365 0.83 MAPT (0.46) MAPTKDM4ENPSR1MAPK1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0843660-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1998-05-27 EP claimed
WO-1997005109-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1997-02-13 WO claimed
EP-0843660-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1998-05-27 EP disclosed
US-5696148-A POTENT ANTAGONIST OF METABOTROPIC GLUTAMATE RECEPTORS; TREATING EPILEPSY, PARKINSON'S DISEASE, HUNTINGTON'S DISEASE, BRAIN DISORDER AND ALZHEIMER'S DISEASE NOVO NORDISK A/S (DK) 1997-12-09 US disclosed
WO-1997005109-A1 HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1997-02-13 WO disclosed