Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | THRA | P10827 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710646 | 0.88 | RAB9A (0.60) | MEN1KMT2AMAPTPOLBBLM | |
| SCHEMBL10943066 | 0.86 | KMT2A (0.94) | MEN1KMT2AMAPTPOLBBLM | |
| SCHEMBL17409104 | 0.84 | MEN1 (0.78) | MEN1KMT2AMAPTPOLBBLM | |
| SCHEMBL32690121 | 0.83 | MEN1 (1.00) | MEN1KMT2AMAPTPOLBBLM | |
| SCHEMBL18300094 | 0.83 | MEN1 (1.00) | MEN1KMT2AMAPTPOLBBLM | |
| SCHEMBL30868371 | 0.82 | KMT2A (0.88) | MEN1KMT2AMAPTPOLBBLM | |
| SCHEMBL299879 | 0.82 | KMT2A (0.88) | MEN1KMT2AMAPTPOLBBLM | |
| SCHEMBL1028236 | 0.81 | KMT2A (0.78) | MEN1KMT2AMAPTPOLBBLM | |
| SCHEMBL1028237 | 0.81 | KMT2A (0.78) | MEN1KMT2AMAPTPOLBBLM | |
| SCHEMBL7748130 | 0.81 | SMN1; SMN2 (0.71) | MEN1KMT2AMAPTPOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |