Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 10/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714767 | 0.88 | MEN1 (0.71) | RAB9ASMN1; SMN2NPC1LMNAMEN1 | |
| SCHEMBL27181188 | 0.87 | SMN1; SMN2 (0.74) | RAB9ASMN1; SMN2NPC1LMNAMEN1 | |
| SCHEMBL30926970 | 0.87 | SMN1; SMN2 (0.74) | RAB9ASMN1; SMN2NPC1LMNAMEN1 | |
| SCHEMBL8710919 | 0.83 | MEN1 (0.80) | RAB9ASMN1; SMN2NPC1LMNAMEN1 | |
| SCHEMBL8711467 | 0.82 | ALOX5 (0.80) | RAB9ASMN1; SMN2NPC1LMNAMEN1 | |
| SCHEMBL7748130 | 0.82 | SMN1; SMN2 (0.71) | RAB9ASMN1; SMN2NPC1LMNAMEN1 | |
| SCHEMBL13265910 | 0.81 | MAPT (0.58) | RAB9ASMN1; SMN2NPC1LMNAMEN1 | |
| SCHEMBL95529 | 0.81 | SMN1; SMN2 (0.66) | RAB9ASMN1; SMN2NPC1LMNAMEN1 | |
| SCHEMBL9329754 | 0.80 | MEN1 (0.85) | RAB9ASMN1; SMN2NPC1LMNAMEN1 | |
| SCHEMBL4446011 | 0.80 | MEN1 (0.76) | RAB9ASMN1; SMN2NPC1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728835-A | HYPOTENSIVE AGENTS; ANTIISCHEMIC AGENTS | TOA EIYO, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0661266-A1 | Substituted cyclic amine compounds as 5HT2 antagonists | TOA EIYO LTD. (JP) | 1995-07-05 | — | — | EP | disclosed |